1. RESEARCH ARTICLE

Preprint, In review

Alternative sulphur metabolism in the fungal pathogen Candida parapsilosis
Lombardi L, Salzberg LI, Ó Cinnéide E, O'Brien CE, Morio F, Turner SA, Byrne KP, Butler G (2024)

DOI: 10.21203/rs.3.rs-3951443/v1

2. RESEARCH ARTICLE

FEMS Yeast Research, 22: foac053.

Identification of European isolates of the lager yeast parent Saccharomyces eubayanus
Bergin SA, Allen S, Hession C, Ó Cinnéide E, Ryan A, Byrne KP, Ó Cróinín T, Wolfe KH and Butler G (2022)

Award: Winner Best Paper of 2022 in FEMS Yeast Research
Commentary: Sampaio JP (2022) FEMS Yeast Research, 22: foac058
DOI: 10.1093/femsyr/foac053
Citations: PubMed
PMID: 36473696

Press: New York Times, RTÉ, Irish Times, The Sun, Daily Mail
Science Press: New Scientist, Science News, Silicon Republic
Press Release: butler.ucd.ie, UCD Research, UCD, NovaUCD

Supplemental:  Supplemental Information  Files 

3. RESEARCH ARTICLE

PLOS Biology, 20: e3001877.

Identification of genetic variants of the industrial yeast Komagataella phaffii (Pichia pastoris) that contribute to increased yields of secreted heterologous proteins
Offei B, Braun-Galleani S, Venkatesh A, Casey WT, O'Connor KE, Byrne KP and Wolfe KH (2022)

Commentary: Swichkow CR, Bloom JS, Kruglyak L (2022) PLOS Biology, 20: e3001911
DOI: 10.1371/journal.pbio.3001877
Citations: PubMed
PMID: 36520709

Supplemental:  Supplemental Information  Figure 1  Supplemental Information  Figure 2  Supplemental Information  Figure 3  Supplemental Information  Figure 4  Supplemental Information  Figure 5 
  Supplemental Information  Figure 6  Supplemental Information  Figure 7  Supplemental Information  Figure 8  Supplemental Information  Figure 9  Supplemental Information  Figure 10 
  Supplemental Information  Data 1  Supplemental Information  Data 2  Supplemental Information  Data 3  Supplemental Information  Data 4   
  Supplemental Information  Table 1  Supplemental Information  Table 2  Supplemental Information  Raw Images 1   

4. RESEARCH ARTICLE

PLOS Genetics, 18: e1010525.

A widespread inversion polymorphism conserved among Saccharomyces species is caused by recurrent homogenization of a sporulation gene family
Salzberg LI, Martos AAR, Lombardi L, Jermiin LS, Blanco A, Byrne KP and Wolfe KH (2022)

DOI: 10.1371/journal.pgen.1010525
Citations: PubMed
PMID: 36441813

Supplemental:  Supplemental Information  Figure 1  Supplemental Information  Figure 2  Supplemental Information  Figure 3  Supplemental Information  Figure 4  Supplemental Information  Figure 5 
  Supplemental Information  Figure 6  Supplemental Information  Figure 7  Supplemental Information  Figure 8  Supplemental Information  Table 1  Supplemental Information  Table 2 
  Supplemental Information  Table 3  Supplemental Information  Table 4  Supplemental Information  Table5  Supplemental Information  File 1  Supplemental Information  Data 1 

5. RESEARCH ARTICLE

eLife, 9: e55336.

The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family
Coughlan AY, Lombardi L, Braun-Galleani S, Martos AAR, Galeote V, Bigey F, Dequin S, Byrne KP and Wolfe KH (2020)

Insight: Rusche L (2020) eLife, 9: e58403
DOI: 10.7554/eLife.55336
Citations: PubMed
PMID: 32338594

Supplemental:  Supplemental Information  File 1  Supplemental Information  File 2  Supplemental Information  File 3 

6. RESEARCH ARTICLE

Microbial Cell Factories, 18: 211.

Genomic diversity and meiotic recombination among isolates of the biotech yeast Komagataella phaffii (Pichia pastoris)
Braun-Galleani S, Dias JA, Coughlan AY, Ryan AP, Byrne KP and Wolfe KH (2019)

DOI: 10.1186/s12934-019-1260-4
Citations: PubMed
PMID: 31801527

Supplemental:  Supplemental Information  File 1  Supplemental Information  File 2  Supplemental Information  File 3  Supplemental Information  File 4 

7. RESEARCH ARTICLE

FEMS Yeast Research, 19: foz058.

The Methylotroph Gene Order Browser (MGOB) reveals conserved synteny and ancestral centromere locations in the yeast family Pichiaceae
Douglass AP, Byrne KP and Wolfe KH (2019)

DOI: 10.1093/femsyr/foz058
Citations: PubMed
PMID: 31397853

Supplemental:  Supplemental Information  Information  MGOB Website  Website 

8. RESEARCH ARTICLE

Scientific Reports, 9: 9240.

The CYPome of the model xenobiotic-biotransforming fungus Cunninghamella elegans
Palmer-Brown W, Miranda-CasoLuengo R, Wolfe KH, Byrne KP and Murphy CD (2019)

DOI: 10.1038/s41598-019-45706-x
Citations: PubMed
PMID: 31239505

Supplemental:  Supplemental Information  Information 

9. RESEARCH ARTICLE

G3, 9: 879-887.

Coverage-versus-Length plots, a simple quality control step for de novo yeast genome sequence assemblies
Douglass AP, O'Brien CE, Offei B, Coughlan AY, Ortiz-Merino RA, Butler G, Byrne KP and Wolfe KH (2019)

DOI: 10.1534/g3.118.200745
Citations: PubMed
PMID: 30674538

Supplemental:  Supplemental Information  Figure 1  Supplemental Information  Figure 2 

10. RESEARCH ARTICLE

Genome Biology and Evolution, 11: 189-206.

Comparative analysis of Oomycete genome evolution using the Oomycete Gene Order Browser (OGOB)
McGowan J, Byrne KP and Fitzpatrick DA (2019)

DOI: 10.1093/gbe/evy267
Citations: PubMed
PMID: 30535146

Supplemental:  Supplemental Information  Information 

11. RESEARCH ARTICLE

PLOS Pathogens, 14: e1007138.

Population genomics shows no distinction between pathogenic Candida krusei and environmental Pichia kudriavzevii: One species, four names
Douglass AP, Offei B, Braun-Galleani S, Coughlan AY, Martos AAR, Ortiz-Merino RA, Byrne KP and Wolfe KH (2018)

DOI: 10.1371/journal.ppat.1007138
Citations: PubMed
PMID: 30024981

• Media: "Two Fungal Species - One Pathogenic, One Benign - Are Actually the Same", The Scientist, 19th July 2018
• Media: "We've Been Putting A Potentially Dangerous, Drug-resistant Yeast in Food for Centuries", Discover Magazine, 19th July 2018

Supplemental:  Supplemental Information  Figure 1  Supplemental Information  Figure 2  Supplemental Information  Figure 3  Supplemental Information  Figure 4 
  Supplemental Information  Table 1  Supplemental Information  Table 2  Supplemental Information  File 1   

12. RESEARCH ARTICLE

Applied and Environmental Microbiology, 84: e02294-17.

Transcriptional response to lactic acid stress in the hybrid yeast Zygosaccharomyces parabailii
Ortiz-Merino RA, Kuanyshev N, Byrne KP, Varela JA, Morrissey JP, Porro D, Wolfe KH and Branduardi P (2018)

DOI: 10.1128/AEM.02294-17
Citations: PubMed
PMID: 29269498

Supplemental:  Supplemental Information  Info  Supplemental Information  Data 1  Supplemental Information  Data 2  Supplemental Information  Data 3 
  Supplemental Information  Data 4  Supplemental Information  Data 5  Supplemental Information  Data 6  Supplemental Information  Data 7 

13. RESEARCH ARTICLE

PLOS Genetics, 13: e1007092.

Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway
Hanson SJ, Byrne KP and Wolfe KH (2017)

DOI: 10.1371/journal.pgen.1007092
Citations: PubMed
PMID: 29176810

Supplemental:  Supplemental Information  Figure 1  Supplemental Information  Figure 2  Supplemental Information  Figure 3  Supplemental Information  Figure 4  Supplemental Information  Figure 5 
  Supplemental Information  Figure 6  Supplemental Information  Figure 7  Supplemental Information  Figure 8  Supplemental Information  Figure 9  Supplemental Information  Figure 10 
  Supplemental Information  Table 1  Supplemental Information  Table 2  Supplemental Information  Table 3  Supplemental Information  Table 4  Supplemental Information  Table 5 
  Supplemental Information  Table 6  Supplemental Information  Table 7             

14. RESEARCH ARTICLE

PLOS Biology, 15: e2002128.

Evolutionary restoration of fertility in an interspecies hybrid yeast, by whole-genome duplication after a failed mating-type switch
Ortiz-Merino RA, Kuanyshev N, Braun-Galleani S, Byrne KP, Porro D, Branduardi P and Wolfe KH (2017)

DOI: 10.1371/journal.pbio.2002128
Citations: PubMed
PMID: 28510588

Supplemental:  Supplemental Information  Figure 1  Supplemental Information  Figure 2  Supplemental Information  Data 1 
  Supplemental Information  Table 1  Supplemental Information  Table 2  Supplemental Information  Table 3 

15. RESEARCH ARTICLE

Genome Biology and Evolution, 8: 2482-92.

Centromeres of the yeast Komagataella phaffii (Pichia pastoris) have a simple inverted-repeat structure
Coughlan AY, Hanson SJ, Byrne KP and Wolfe KH (2016)

DOI: 10.1093/gbe/evw178
Citations: PubMed
PMID: 27497317

Supplemental:  Supplemental Information  Information 

16. REVIEW ARTICLE

FEMS Yeast Research, 15: fov035.

Clade- and species-specific features of genome evolution in the Saccharomycetaceae
Wolfe KH, Armisén D, Proux-Wera E, ÓhÉigeartaigh SS, Azam H, Gordon JL and Byrne KP (2015)

DOI: 10.1093/femsyr/fov035
Citations: PubMed
PMID: 26066552

17. RESEARCH ARTICLE

PNAS, 111: E4851-8.

Mating type switching by chromosomal inversion in methylotrophic yeasts suggests an origin for the three-locus Saccharomyces cerevisiae system
Hanson SJ, Byrne KP and Wolfe KH (2014)

DOI: 10.1073/pnas.1416014111
Citations: PubMed
PMID: 25349420

Supplemental:  Supplemental Information  Information 

18. RESEARCH ARTICLE

Journal of Bacteriology, 196: 2030-2042.

SearchDOGS Bacteria, software that provides automated identification of potentially missed genes in annotated bacterial genomes
ÓhÉigeartaigh SS, Armisén D, Byrne KP and Wolfe KH (2014)

DOI: 10.1128/JB.01368-13
Citations: PubMed
PMID: 24659774

Supplemental:  Supplemental Information  File 1 

19. RESEARCH ARTICLE

Molecular Biology and Evolution, 30: 1281-1291.

Comparative genome analysis and gene finding in Candida species using CGOB
Maguire S, ÓhÉigeartaigh SS, Byrne KP, Schroeder M, O'Gaora P, Wolfe KH and Butler G (2013)

DOI: 10.1093/molbev/mst042
Citations: PubMed
PMID: 23486613

Supplemental:  Supplemental Table 1  Table 1 

20. RESEARCH ARTICLE

Genome Biology and Evolution, 5: 525-531.

Evolutionary mobility of the ribosomal DNA array in yeasts
Proux-Wéra E, Byrne KP and Wolfe KH (2013)

DOI: 10.1093/gbe/evt022
Citations: PubMed
PMID: 23419706

21. RESEARCH ARTICLE

BMC Bioinformatics, 13: 237.

A pipeline for automated annotation of yeast genome sequences by a conserved-synteny approach
Proux-Wéra E, Armisén D, Byrne KP and Wolfe KH (2012)

DOI: 10.1186/1471-2105-13-237
Citations: PubMed
PMID: 22984983

22. RESEARCH ARTICLE

PNAS, 108: 20024-20029.

Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents
Gordon JL, Armisén D, Proux-Wéra E, ÓhÉigeartaigh SS, Byrne KP and Wolfe KH (2011)

DOI: 10.1073/pnas.1112808108
Citations: PubMed
PMID: 22123960

Supplemental:  Supplemental Information  /  Supplemental Information  Information

23. RESEARCH ARTICLE

PLOS Genetics, 7: e1002190.

Mechanisms of chromosome number evolution in yeast
Gordon JL, Byrne KP and Wolfe KH (2011)

Community Choice: A story of chromosome number (2011) Nature, 477: 9
DOI: 10.1371/journal.pgen.1002190
Citations: PubMed
PMID: 21811419

• Media: "Scientists trace yeast's gene shuffle", Australian Broastcasting Corporation, 22nd July 2011

Supplemental:  Supplemental Information  Dataset 1  Supplemental Information  Figure 1  Supplemental Information  Figure 2  Supplemental Information  Figure 3  Supplemental Information  Table 1
  Supplemental Information  Table 2  Supplemental Information  Table 3  Supplemental Information  Table 4  Supplemental Information  Table 5  Supplemental Information  Table 6

24. RESEARCH ARTICLE

BMC Genomics, 12: 377.

Systematic discovery of unannotated genes in 11 yeast species using a database of orthologous genomic segments
OhEigeartaigh SS, Armisen D, Byrne KP and Wolfe KH (2011)

DOI: 10.1186/1471-2164-12-377
Citations: PubMed
PMID: 21791067

Supplemental:  Supplemental Information  File 1 

25. RESEARCH ARTICLE

BMC Genomics, 11: 290.

Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser
Fitzpatrick DA, O'Gaora P, Byrne KP and Butler G (2010)

DOI: 10.1186/1471-2164-11-290
Citations: PubMed
PMID: 20459735

Supplemental:  Supplemental Information  File 1  Supplemental Information  File 2  Supplemental Information  File 3  Supplemental Information  File 4  Supplemental Information  File 5  CGOB Website  Website 

26. RESEARCH ARTICLE

PLOS Genetics, 5: e1000485.

Additions, losses and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome
Gordon JL, Byrne KP and Wolfe KH (2009)

Perspective: Sankoff D (2009) PLOS Genetics, 5: e1000483
Highlights: Neame E (2009) Nature Reviews Genetics, 10: 426
DOI: 10.1371/journal.pgen.1000485
Citations: PubMed
PMID: 19436716

Supplemental:  Supplemental Information  Figure 1  Supplemental Information  Table 1  Supplemental Information  Table 2

27. RESEARCH ARTICLE

PNAS, 104: 8397-8402.

Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication
Scannell DR, Frank AC, Conant GC, Byrne KP, Woolfit M and Wolfe KH (2007)

DOI: 10.1073/pnas.0608218104
Citations: PubMed
PMID: 17494770

Supplemental:  Supplemental Information  /  Supplemental Information  Information

28. RESEARCH ARTICLE

Genetics, 175: 1341-1350.

Consistent patterns of rate asymmetry and gene loss indicate widespread neo-functionalization of yeast genes after whole-genome duplication
Byrne KP and Wolfe KH (2007)

Issue Highlights: Genetics, 2007; 175: NP
DOI: 10.1534/genetics.106.066951
Citations: PubMed
PMID: 17194778

Supplemental:  Supplemental Information  Information

29. RESEARCH ARTICLE

Nature, 440: 341-345.

Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts
Scannell DR*, Byrne KP*, Gordon JL, Wong S and Wolfe KH (2006)

DOI: 10.1038/nature04562
Citations: PubMed
PMID: 16541074

• Press: Dick Ahlstrom, Science Editor, Irish Times, 3rd March 2006
  "Demonstrating the origin of a species"

* These authors contributed equally to this work.

Supplemental:  Supplemental Table 1 - 
Biased representation of Gene Ontology (GO) terms in gene loss classes  Table 1  Supplemental Note 2 - Phylogenetic relationship among S. castellii, S. cerevisiae and C. glabrata  Note 2  Supplemental Note 3 - Estimation of relative timing of speciation events  Note 3  Supplemental Note 4 - Model-based estimation of the number of genes still duplicated at phylogenetic nodes  Note 4  Supplemental Note 5 - Overrepresentation of slowly evolving genes and genes involved in highly conserved biological processes among genes that underwent RGL  Note 5 

30. RESEARCH ARTICLE

Nucleic Acids Research, 34: D452-455.

Visualizing syntenic relationships among the hemiascomycetes with the Yeast Gene Order Browser
Byrne KP and Wolfe KH (2006)

DOI: 10.1093/nar/gkj041
Citations: PubMed
PMID: 16381909

31. RESEARCH ARTICLE

Molecular Biology and Evolution, 23: 245-253.

Rate asymmetry and adaptive evolution after genome duplication causes substantial long branch attraction artifacts in the phylogeny of Saccharomyces species
Fares MA, Byrne KP and Wolfe KH (2006)

DOI: 10.1093/molbev/msj027
Citations: PubMed
PMID: 16207937

Supplemental:  Supplemental Table 1 - Distances and ratios of distances from each S. cerevisiae ohnolog to their C. albicans ortholog  Table 1

32. REVIEW ARTICLE

Current Bioinformatics, 1: 131-146.

Computational analyses of ancient polyploidy
Byrne KP and Blanc G (2006)

DOI: 10.2174/157489306777011897

33. RESEARCH ARTICLE

Genome Research, 15: 1456-1461.

The Yeast Gene Order Browser: Combining curated homology and syntenic context reveals gene fate in polyploid species
Byrne KP and Wolfe KH (2005)

DOI: 10.1101/gr.3672305
Citations: PubMed
PMID: 16169922

Supplemental:  Supplemental Methods  Methods  Supplemental Table 1 - Gene sets, homology, tandem repeats and ohnologs  Table 1  Supplemental Table 2 - Full Ohnolog Lists from S. cerevisiae, S. castellii and C. glabrata  Table 2  YGOB Data  Data  YGOB Website  Website 
Dr Kevin Byrne
Conway Institute
UCD School of Medicine
University College Dublin
Belfield
Dublin 4
Ireland
fb.com/drkevinbyrne
@drkevinbyrne


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Ph.D. Thesis

Post-polyploidy evolution
in yeasts
Kevin Byrne (2007)

Trinity College Library Dublin
THESIS 8198

Supervisor: Prof. Kenneth H. Wolfe
Department of Genetics,
Trinity College, Dublin 2, Ireland.

0000-0002-6368-154X

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